This writer explores some glaring biblical instances of both individual and collaborative conflicts against the purposes of God and his delegates on earth. Practical approaches on how to handle devilish agents of opposition in all leadership settings are gleaned. Some fingertip suggestions offered to acquaint Christians and secular heads with multiple approaches to problem makers in the society. There are a variety of cases of oppositions in the Bible as well as how God led his servants to overcome them with success. This book is divided into two parts: Part one comprises of five chapters. Chapter one is an identification of the earliest cases of opposition from the serpent to the patriarchal tensions. Chapter two showcases human opposition of God’s purposes as recorded in the book of Exodus, during the narrow escape of the Hebrews from Egypt. In the third chapter, an investigation into the acts of turbulent rebels against God in the period of the settlement to the period of the monarchy was made. Chapter four considers vipers in wisdom literature and the runaway of a rebel prophet who became prey to a whale! Chapter five beautifully wraps up some opposing viper in the gospels, the Acts of the Apostles, rounding up the treatment with the deadly vipers of Apocalyptic-the Dragon, the two Beasts and the controversial prostitute ably but dangerously represented by the mistress Babylon, the head teacher of harlots.